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Markus Kraus
Anett Georgi
Katrin Mackenzie
Ulf Roland
Navid Saeidi
Ariette Schierz
Carsten Vogt
Ivonne Nijenhuis
Matthias Gehre
Steffen Kümmel
Matthias Schmidt
Hryhoriy Stryhanyuk
Frank Holzer
Pegah Fatehbasharzad
Shuting Li
Haojie Zhang
Felix Weinhardt
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Ivonne Nijenhuis
Dr. Ivonne Nijenhuis
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Contact / Address:
E-mail
ivonne.nijenhuis@ufz.de
Phone + 49 (0) 341 6025 1356
Helmholtz Centre for Environmental Research - UFZ
Permoserstrasse 15
04318 Leipzig
Curriculum Vitae
2004 -current
Senior Scientist, Department Technical Biogeochemistry (up to 2023 Isotope Biogeochemistry)
from 04.2022
Member of the Works Council
09.2022-12.2023
Staff Unit Change Manangement // Internationalisation Consultant
04.2020- 08.2022
Scientific Manager Integration Platform 'Tapping nature's potential for sustainable production and a healthy environment-TapNature'; Research Unit Environmental Engineering and Biotechnology
2009-2020
Working Group Leader 'organohalide geomicrobiology'
2016
Habilitation in natural sciences, Martin-Luther-University Halle-Wittenberg, Germany
2013
Certified Manager, Helmholtz Academy for managers Malik Management Centre St. Gallen
2010-2015
Coordinator European Union FP7 'People' programme Initial Training Network CSI:ENVIRONMENT
2009-2017
Elected employee representative member of the supervisory board of the UFZ
2002 -
2004
Post-Doctoral Scientist EU Marie Curie Host Development fellowship (BIOISOTOPE) European expert in Anaerobic Microbiology, UFZ-Leipzig
2002
Ph.D. in Microbiology; Cornell University, USA
1996
M.Sc. in Environmental Sciences; Wageningen Agricultural University, the Netherlands
Professional & Research interests
My research in the Department of technical Biogeochemistry focuses on the anaerobic biotransformation of halogenated organic contaminants and the application of stable isotope concepts. Currently, these are applied in the BMBF funded project KONATES, addressing the question on how aquifer thermal energy storage affects the in situ biotransformation of halogenated groundwater contaminants, i.e. chlorinated ethenes.
My main expertise include 1) understanding of microbial transformation of chlorinated and brominated ethenes and ethanes, halogenated pesticides, e.g. hexachlorocyclohexane, and pharmaceuticals, e.g. diclofenac, and 2)  development and application of multi-element compound-specific stable isotope (C, Cl, Br, H) fractionation as a tool to analyse microbial reactions and biotransformation in situ.
Projects
2011-2019 the DFG Forschergruppe "FOR1530 'Anaerobic Dehalogenation: Organisms, Biochemistry and (Eco-) Physiology'" links research groups in Jena, Halle and Leipzig.
Within this project, I was in charge of sub-project 05: 'Characterisation
of microbial dehalogenation using compound specific stable isotope
analysis'.
Within the European Union FP7 project "GENESIS" we investigated how biogeochemical processes affect natural attenuation of chlorinated benzenes and are focusing on the microbial community involved in contaminant biotransformation.
From 2010-2015, I coordinated the European Union FP7 'People' programme Initial Training Network "CSI:ENVIRONMENT". In this project, 10 Partners and 4 Associated Partners from 9 European countries will work on 'Isotope forensics meets biogeochemistry - linking sources and sinks of organic contaminants by compound specific isotope investigation'.
2012-2014, Joint German-Israeli Water Technology Programme “Development of innovative tools for the assessment of in situ biodegradation of organobromine contaminant in groundwater” – INTIME. In this 3 year project we will investigate the application of CSIA for assessment of the natural attenuation of brominated groundwater contaminants.
Publications (in co-operation with the UFZ)
Bashir, S., Fischer, A., Nijenhuis, I., Richnow, H.H. (2013):
Enantioselective carbon stable isotope fractionation of hexachlorocyclohexane during aerobic biodegradation by Sphingobium spp.
Environ. Sci. Technol. 47 (20), 11432 - 11439
10.1021/es402197s
Bashir, S., Kuntze, K., Vogt, C., Nijenhuis, I. (2018):
Anaerobic biotransformation of hexachlorocyclohexane isomers by Dehalococcoides species and an enrichment culture
Biodegradation 29 (4), 409 - 418
10.1007/s10532-018-9838-9
Bin Hudari, M.S., Deb, S., Vogt, C., Filippini, M., Nijenhuis, I. (2025):
Temperature-associated effects on methanogenesis and microbial reductive dechlorination of trichloroethene in contaminated aquifer sediments
Front. Water 7 , art. 1566161
10.3389/frwa.2025.1566161
Bin Hudari, M.S., Richnow, H., Vogt, C., Nijenhuis, I. (2022):
Effect of temperature on microbial reductive dehalogenation of chlorinated ethenes: a review
FEMS Microbiol. Ecol. 98 (9), fiac081
10.1093/femsec/fiac081
Birkigt, J., Gilevska, T., Ricken, B., Richnow, H.-H., Vione, D., Corvini, P.F.-X., Nijenhuis, I., Cichocka, D. (2015):
Carbon stable isotope fractionation of sulfamethoxazole during biodegradation by Microbacterium sp. strain BR1 and upon direct photolysis
Environ. Sci. Technol. 49 (10), 6029 - 6036
10.1021/acs.est.5b00367
Birkigt, J., Stumpp, C., Małoszewski, P., Nijenhuis, I. (2018):
Evaluation of the hydrological flow paths in a gravel bed filter modeling a horizontal subsurface flow wetland by using a multi-tracer experiment
Sci. Total Environ. 621 , 265 - 272
10.1016/j.scitotenv.2017.11.217
Cichocka, D., Imfeld, G., Richnow, H.H., Nijenhuis, I. (2008):
Variability in microbial carbon isotope fractionation of tetra- and trichloroethene upon reductive dechlorination
Chemosphere 71 (4), 639 - 648
10.1016/j.chemosphere.2007.11.013
Cichocka, D., Nikolausz, M., Haest, P.J., Nijenhuis, I. (2010):
Tetrachloroethene conversion to ethene by a Dehalococcoides-containing enrichment culture from Bitterfeld
FEMS Microbiol. Ecol. 72 (2), 297 - 310
10.1111/j.1574-6941.2010.00845.x
Cichocka, D., Siegert, M., Imfeld, G., Andert, J., Beck, K., Diekert, G., Richnow, H.H., Nijenhuis, I. (2007):
Factors controlling the carbon isotope fractionation of tetra- and trichloroethene during reductive dechlorination by Sulfurospirillum ssp. and Desulfitobacterium sp. strain PCE-S
FEMS Microbiol. Ecol. 62 (1), 98 - 107
10.1111/j.1574-6941.2007.00367.x
Duldhardt, I., Gaebel, J., Chrzanowski, Ł., Nijenhuis, I., Schauer, F., Heipieper, H.J. (2010):
Adaptation of anaerobically grown Thauera aromatica, Geobacter sulfurreducens and Desulfococcus multivorans to organic solvents on the level of membrane fatty acid composition
Microb. Biotechnol. 3 (2), 201 - 209
10.1111/j.1751-7915.2009.00124.X
Duldhardt, I., Nijenhuis, I., Schauer, F., Heipieper, H.J. (2007):
Anaerobically grown Thauera aromatica, Desulfococcus multivorans, Geobacter sulfurreducens are more sensitive towards organic solvents than aerobic bacteria
Appl. Microbiol. Biotechnol. 77 (3), 705 - 711
10.1007/s00253-007-1179-2
Elsayed, O.F., Maillard, E., Vuilleumier, S., Nijenhuis, I., Richnow, H.H., Imfeld, G. (2014):
Using compound-specific isotope analysis to assess the degradation of chloroacetanilide herbicides in lab-scale wetlands
Chemosphere 99 , 89 - 95
10.1016/j.chemosphere.2013.10.027
Ewald, E.-M., Wagner, A., Nijenhuis, I., Richnow, H.H., Lechner, U. (2007):
Microbial dehalogenation of trichlorinated dibenzo-p-dioxins by a Dehalococcoides-containing mixed culture is coupled to carbon isotope fractionation
Environ. Sci. Technol. 41 (22), 7744 - 7751
10.1021/es070935g
Fennell, D.E., Nijenhuis, I., Wilson, S.F., Zinder, S.H., Häggblom, M.M. (2004):
Dehalococcoides ethenogenes strain 195 reductively dechlorinates diverse chlorinated aromatic pollutants
Environ. Sci. Technol. 38 (7), 2075 - 2081
10.1021/es034989b
Filippini, M., Amorosi, A., Campo, B., Herrero-Martìn, S., Nijenhuis, I., Parker, B.L., Gargini, A. (2016):
Origin of VC-only plumes from naturally enhanced dechlorination in a peat-rich hydrogeologic setting
J. Contam. Hydrol. 192 , 129 - 139
10.1016/j.jconhyd.2016.07.003
Filippini, M., Nijenhuis, I., Kümmel, S., Chiarini, V., Crosta, G., Richnow, H.H., Gargini, A. (2018):
Multi-element compound specific stable isotope analysis of chlorinated aliphatic contaminants derived from chlorinated pitches
Sci. Total Environ. 640-641 , 153 - 162
10.1016/j.scitotenv.2018.05.285
Filippini, M., Stumpp, C., Nijenhuis, I., Richnow, H.H., Gargini, A. (2015):
Evaluation of aquifer recharge and vulnerability in an alluvial lowland using environmental tracers
J. Hydrol. 529 , 1657 - 1668
10.1016/j.jhydrol.2015.07.055
Fletcher, K.E., Löffler, F.E., Richnow, H.-H., Nijenhuis, I. (2009):
Stable carbon isotope fractionation of 1,2-Dichloropropane during dichloroelimination by Dehalococcoides populations
Environ. Sci. Technol. 43 (18), 6915 - 6919
10.1021/es900365x
Fletcher, K.E., Nijenhuis, I., Richnow, H.-H., Löffler, F.E. (2011):
Stable carbon isotope enrichment factors for cis-1,2-dichloroethene and vinyl chloride reductive dechlorination by Dehalococcoides
Environ. Sci. Technol. 45 (7), 2951 - 2957
10.1021/es103728q
Franke, S., Kümmel, S., Nijenhuis, I. (2018):
Liquid chromatography/isotope ratio mass spectrometry analysis of halogenated benzoates for characterization of the underlying degradation reaction in Thauera chlorobenzoica CB‐1T
Rapid Commun. Mass Spectrom. 32 (11), 906 - 912
10.1002/rcm.8113
Franke, S., Lihl, C., Renpenning, J., Elsner, M., Nijenhuis, I. (2017):
Triple-element compound-specific stable isotope analysis of 1,2-dichloroethane for characterization of the underlying dehalogenation reaction in two Dehalococcoides mccartyi strains
FEMS Microbiol. Ecol. 93 (12), fix137
10.1093/femsec/fix137
Franke, S., Seidel, K., Adrian, L., Nijenhuis, I. (2020):
Dual element (C/Cl) isotope analysis indicates distinct mechanisms of reductive dehalogenation of chlorinated ethenes and dichloroethane in Dehalococcoides mccartyi strain BTF08 with defined reductive dehalogenase inventories
Front. Microbiol. 11 , art. 1507
10.3389/fmicb.2020.01507
Gilevska, T., Sullivan Ojeda, A., Renpenning, J., Kümmel, S., Gehre, M., Nijenhuis, I. (2020):
Requirements for chromium reactors for use in the determination of H isotopes in compound-specific stable isotope analysis cf chlorinated compounds
Anal. Chem. 92 (3), 2383 - 2387
10.1021/acs.analchem.9b04737
Günthel, M., Klawonn, I., Woodhouse, J., Bižić, M., Ionescu, D., Ganzert, L., Kümmel, S., Nijenhuis, I., Zoccarato, L., Grossart, H.-P., Tang, K.W. (2020):
Photosynthesis‐driven methane production in oxic lake water as an important contributor to methane emission
Limnol. Oceanogr. 65 (12), 2853 - 2865
10.1002/lno.11557
Herrero, J., Puigserver, D., Nijenhuis, I., Kuntze, K., Carmona, J.M. (2022):
Key factors controlling microbial distribution on a DNAPL source area
Environ. Sci. Pollut. Res. 29 (1), 1508 - 1520
10.1007/s11356-021-15635-2
Herrero, J., Puigserver, D., Nijenhuis, I., Kuntze, K., Carmona, J.M. (2019):
Combined use of ISCR and biostimulation techniques in incomplete processes of reductive dehalogenation of chlorinated solvents
Sci. Total Environ. 648 , 819 - 829
10.1016/j.scitotenv.2018.08.184
Herrero, J., Puigserver, D., Nijenhuis, I., Kuntze, K., Parker, B.L., Carmona, J.M. (2021):
The role of ecotones in the dehalogenation of chloroethenes in alluvial fan aquifers
Environ. Sci. Pollut. Res. 28 (21), 26871 - 26884
10.1007/s11356-021-12538-0
Herrero-Martín, S., Nijenhuis, I., Richnow, H.H., Gehre, M. (2015):
Coupling of a headspace autosampler with a programmed temperature vaporizer for stable carbon and hydrogen isotope analysis of volatile organic compounds at microgram per liter concentrations
Anal. Chem. 87 (2), 951 - 959
10.1021/ac503229e
Holliger, C., Nijenhuis, I. (2018):
Special issue on anaerobic biological dehalogenation. Editorial
FEMS Microbiol. Ecol. 94 (6), fiy054
10.1093/femsec/fiy054
Horna-Gray, I., Lopez, N.A., Nijenhuis, I., Ahn, Y., Richnow, H.H., Häggblom, M.M. (2020):
Reductive debromination by sponge-associated anaerobic bacteria coupled to carbon isotope fractionation
Int. Biodeterior. Biodegrad. 155 , art. 105093
10.1016/j.ibiod.2020.105093
Imfeld, G., Aragonés, C.E., Fetzer, I., Mészáros, E., Zeiger, S., Nijenhuis, I., Nikolausz, M., Delerce, S., Richnow, H.H. (2010):
Characterization of microbial communities in the aqueous phase of a constructed model wetland treating 1,2-dichloroethene-contaminated groundwater
FEMS Microbiol. Ecol. 72 (1), 74 - 88
10.1111/j.1574-6941.2009.00825.x
Imfeld, G., Nijenhuis, I., Nikolausz, M., Zeiger, S., Paschke, H., Drangmeister, J., Grossmann, J., Richnow, H.H., Weber, S. (2008):
Assessment of in situ degradation of chlorinated ethenes and bacterial community structure in a complex contaminated groundwater system
Water Res. 42 (4-5), 871 - 882
10.1016/j.watres.2007.08.035
Imfeld, G., Pieper, H., Shani, N., Rossi, P., Nikolausz, M., Nijenhuis, I., Paschke, H., Weiß, H., Richnow, H.H. (2011):
Characterization of groundwater microbial communities, dechlorinating bacteria, and in situ biodegradation of chloroethenes along a vertical gradient
Water Air Soil Pollut. 221 (1-4), 107 - 122
10.1007/s11270-011-0774-0
Jin, B., Nijenhuis, I., Rolle, M. (2018):
Simulation of dual carbon–bromine stable isotope fractionation during 1,2-dibromoethane degradation
Isot. Environ. Health Stud. 54 (4), 418 - 434
10.1080/10256016.2018.1468759
Kaschl, A., Vogt, C., Uhlig, S., Nijenhuis, I., Weiß, H., Kästner, M., Richnow, H.H. (2005):
Isotopic fractionation indicates anaerobic monochlorobenzene biodegradation
Environ. Toxicol. Chem. 24 (6), 1315 - 1324
10.1897/04-321R.1
Kästner, M., Fischer, A., Nijenhuis, I., Geyer, R., Stelzer, N., Bombach, P., Tebbe, C.C., Richnow, H.H. (2006):
Assessment of microbial in situ activity in contaminated aquifers
Eng. Life Sci. 6 (3), 234 - 251
10.1002/elsc.200620125
Kaufhold, T., Schmidt, M., Cichocka, D., Nikolausz, M., Nijenhuis, I. (2013):
Dehalogenation of diverse halogenated substrates by a highly enriched Dehalococcoides-containing culture derived from the contaminated mega-site in Bitterfeld
FEMS Microbiol. Ecol. 83 (1), 176 - 188
10.1111/j.1574-6941.2012.01462.x
Khan, M.I., Yoo, K., Schwab, L., Kümmel, S., Nijenhuis, I. (2024):
Characterization of anaerobic biotransformation of hexachlorocyclohexanes by novel microbial consortia enriched from channel and river sediments
J. Hazard. Mater. 476 , art. 135198
10.1016/j.jhazmat.2024.135198
Kjellerup, B.V., Nijenhuis, I., Rossetti, S. (2022):
Editorial: Thematic issue on anaerobic biological dehalogenation
FEMS Microbiol. Ecol. 98 (11), fiac108
10.1093/femsec/fiac108
Knight, V.K., Nijenhuis, I., Kerkhof, L.J., Häggblom, M.M. (2002):
Degradation of aromatic compounds coupled to selenate reduction
Geomicrobiol. J.  19 (1), 77 - 86
10.1080/014904502317246183
Kret, E., Kiecak, A., Malina, G., Nijenhuis, I., Postawa, A. (2015):
Identification of TCE and PCE sorption and biodegradation parameters in a sandy aquifer for fate and transport modelling: batch and column studies
Environ. Sci. Pollut. Res. 22 (13), 9877 - 9888
10.1007/s11356-015-4156-9
Kruse, S., Türkowsky, D., Birkigt, J., Matturro, B., Franke, S., Jehmlich, N., von Bergen, M., Westermann, M., Rossetti, S., Nijenhuis, I., Adrian, L., Diekert, G., Goris, T. (2021):
Interspecies metabolite transfer and aggregate formation in a co-culture of Dehalococcoides and Sulfurospirillum dehalogenating tetrachloroethene to ethene
ISME J.  15 (6), 1794 - 1809
10.1038/s41396-020-00887-6
Kuntze, K., Kozell, A., Richnow, H.H., Halicz, L., Nijenhuis, I., Gelman, F. (2016):
Dual carbon–bromine stable isotope analysis allows distinguishing transformation pathways of ethylene dibromide
Environ. Sci. Technol. 50 (18), 9855 - 9863
10.1021/acs.est.6b01692
Langenhoff, A., Nijenhuis, I., Tan, N.C.G., Briglia, M., Zehnder, A.J.B., Schraa, G. (1997):
Characterisation of a manganese-reducing, toluene-degrading enrichment culture
FEMS Microbiol. Ecol. 24 (2), 113 - 125
10.1111/j.1574-6941.1997.tb00428.x
Lian, S., Nikolausz, M., Nijenhuis, I., Leite, A.F., Richnow, H.H. (2018):
Biotransformation and inhibition effects of hexachlorocyclohexanes during biogas production from contaminated biomass characterized by isotope fractionation concepts
Bioresour. Technol. 250 , 683 - 690
10.1016/j.biortech.2017.11.076
Lian, S., Nikolausz, M., Nijenhuis, I., Nunes da Rocha, U., Liu, B., Borim Corrêa, F., Saraiva, J.P., Richnow, H.H. (2020):
Biotransformation of hexachlorocyclohexanes contaminated biomass for energetic utilization demonstrated in continuous anaerobic digestion system
J. Hazard. Mater. 384 , art. 121448
10.1016/j.jhazmat.2019.121448
Lihl, C., Douglas, L.M., Franke, S., Pérez-de-Mora, A., Meyer, A.H., Daubmeier, M., Edwards, E.A., Nijenhuis, I., Sherwood Lollar, B., Elsner, M. (2019):
Mechanistic dichotomy in bacterial trichloroethene dechlorination revealed by carbon and chlorine isotope effects
Environ. Sci. Technol. 53 (8), 4245 - 4254
10.1021/acs.est.8b06643
Liu, F., Cichocka, D., Nijenhuis, I., Richnow, H.H., Fennell, D.E. (2010):
Carbon isotope fractionation during dechlorination of 1,2,3,4-tetrachlorodibenzo-p-dioxin by a Dehalococcoides-containing culture
Chemosphere 80 (10), 1113 - 1119
10.1016/j.chemosphere.2010.06.027
Liu, Y., Bashir, S., Stollberg, R., Trabitzsch, R., Weiß, H., Paschke, H., Nijenhuis, I., Richnow, H.-H. (2017):
Compound specific and enantioselective stable isotope analysis as tools to monitor transformation of hexachlorocyclohexane (HCH) in a complex aquifer system
Environ. Sci. Technol. 51 (16), 8909 - 8916
10.1021/acs.est.6b05632
Liu, Y., Fu, J., Wu, L., Kümmel, S., Nijenhuis, I., Richnow, H.H. (2022):
Characterization of hexachlorocyclohexane isomer dehydrochlorination by LinA1 and LinA2 using multi-element compound-specific stable isotope analysis
Environ. Sci. Technol. 56 (23), 16848 - 16856
10.1021/acs.est.2c05334
Liu, Y., Kümmel, S., Yao, J., Nijenhuis, I., Richnow, H.-H. (2020):
Dual C–Cl isotope analysis for characterizing the anaerobic transformation of α, β, γ, and δ-hexachlorocyclohexane in contaminated aquifers
Water Res. 184 , art. 116128
10.1016/j.watres.2020.116128
Liu, Y., Renpenning, J., Nijenhuis, I., Richnow, H.-H. (2020):
Dual C–Cl isotope analysis for characterizing the reductive dechlorination of α- and γ-hexachlorocyclohexane by two Dehalococcoides mccartyi strains and an enrichment culture
Environ. Sci. Technol. 54 (12), 7250 - 7260
10.1021/acs.est.9b06407
Liu, Y., Wu, L., Kohli, P., Kumar, R., Stryhanyuk, H., Nijenhuis, I., Lal, R., Richnow, H.-H. (2019):
Enantiomer and carbon isotope fractionation of α-hexachlorocyclohexane by Sphingobium indicum strain B90A and the corresponding enzymes
Environ. Sci. Technol. 53 (15), 8715 - 8724
10.1021/acs.est.9b01233
Lünsmann, V., Kappelmeyer, U., Taubert, A., Nijenhuis, I., von Bergen, M., Heipieper, H.J., Müller, J.A., Jehmlich, N. (2016):
Aerobic toluene degraders in the rhizosphere of a constructed wetland model show diurnal polyhydroxyalkanoate metabolism
Appl. Environ. Microb. 82 (14), 4126 - 4132
10.1128/AEM.00493-16
Marco-Urrea, E., Nijenhuis, I., Adrian, L. (2011):
Transformation and carbon isotope fractionation of tetra- and trichloroethene to Trans-Dichloroethene by Dehalococcoides sp. strain CBDB1
Environ. Sci. Technol. 45 (4), 1555 - 1562
10.1021/es1023459
Martínez-Lavanchy, P.M., Chen, Z., Lünsmann, V., Marin-Cevada, V., Vilchez-Vargas, R., Pieper, D.H., Reiche, N., Kappelmeyer, U., Imparato, V., Junca, H., Nijenhuis, I., Müller, J.A., Kuschk, P., Heipieper, H.J. (2015):
Microbial toluene removal in hypoxic model constructed wetlands occurs predominantly via the ring monooxygenation pathway
Appl. Environ. Microb. 81 (18), 6241 - 6252
10.1128/AEM.01822-15
Martínez-Lavanchy, P.M., Dohrmann, A.B., Imfeld, G., Trescher, K., Tebbe, C.C., Richnow, H.-H., Nijenhuis, I. (2011):
Detection of monochlorobenzene metabolizing bacteria under anoxic conditions by DNA-stable isotope probing
Biodegradation 22 (5), 973 - 982
10.1007/s10532-011-9456-2
Martínez-Lavanchy, P.M., Müller, C., Nijenhuis, I., Kappelmeyer, U., Buffing, M., McPherson, K., Heipieper, H.J. (2010):
High stability and fast recovery of expression of the TOL plasmid-carried toluene catabolism genes of Pseudomonas putida mt-2 under conditions of oxygen limitation and oscillation
Appl. Environ. Microb. 76 (20), 6715 - 6723
10.1128/AEM.01039-10
Maymó-Gatell, X., Nijenhuis, I., Zinder, S.H. (2001):
Reductive dechlorination of cis-1,2-dichlorethene and vinyl chloride by "Dehalococcoides ethenogenes"
Environ. Sci. Technol. 35 (3), 516 - 521
10.1021/es001285i
Mendler, A., Geier, F., Haange, S.-B., Pierzchalski, A., Krause, J.L., Nijenhuis, I., Froment, J., Jehmlich, N., Berger, U., Ackermann, G., Rolle-Kampczyk, U., von Bergen, M., Herberth, G. (2020):
Mucosal-associated invariant T-Cell (MAIT) activation is altered by chlorpyrifos- and glyphosate-treated commensal gut bacteria
J. Immunotoxicol. 17 (1), 10 - 20
10.1080/1547691X.2019.1706672
Mészáros, E., Imfeld, G., Nikolausz, M., Nijenhuis, I. (2013):
Occurrence of Dehalococcoides and reductive dehalogenase genes in microcosms, a constructed wetland and groundwater from a chlorinated ethene contaminated field site as indicators for in situ reductive dehalogenation
Water Air Soil Pollut. 224 (11), art. 1768
10.1007/s11270-013-1768-x
Mortan, S.H., Martín-González, L., Vicent, T., Caminal, G., Nijenhuis, I., Adrian, L., Marco-Urrea, E. (2017):
Detoxification of 1,1,2-trichloroethane to ethene in a bioreactor co-culture of Dehalogenimonas and Dehalococcoides mccartyi strains
J. Hazard. Mater. 331 , 218 - 225
10.1016/j.jhazmat.2017.02.043
Nijenhuis, I., Andert, J., Beck, K., Kästner, M., Diekert, G., Richnow, H.H. (2005):
Stable isotope fractionation of tetrachloroethene during reductive dechlorination by Sulfurospirillum multivorans and Desulfitobacterium sp. strain PCE-S and abiotic reactions with cyanocobalamin
Appl. Environ. Microb. 71 (7), 3413 - 3419
10.1128/aem.71.7.3413-3419.2005
Nijenhuis, I., Andert, J., Beck, K., Vieth, A., Kästner, M., Richnow, H.H., Diekert, G. (2004):
Use of stable isotope fractionation for the assessment of bioattenuation of chlorinated ethenes
In: Verstraete, W. (ed.)
European Symposium on Environmental Biotechnology : proceedings of the European Symposium on Environmental Biotechnology, ESEB 2004, 25-28 April 2004, Oostende, Belgium
Balkema, Leiden, p. 209 - 212
Nijenhuis, I., Kuntze, K. (2016):
Anaerobic microbial dehalogenation of organohalides — state of the art and remediation strategies
Curr. Opin. Biotechnol. 38 , 33 - 38
10.1016/j.copbio.2015.11.009
Nijenhuis, I., Martínez, P., Junca, H., Stelzer, N., Imfeld, G., Weber, S., Richnow, H. (2009):
In situ investigation of microbial diversity and anaerobic chlorobenzene degradation along a vertical gradient
Geochim. Cosmochim. Acta 73 (13 Suppl.), A943
10.1016/j.gca.2009.05.024
Nijenhuis, I., Nikolausz, M., Köth, A., Felföldi, T., Weiß, H., Drangmeister, J., Großmann, J., Kästner, M., Richnow, H.H. (2007):
Assessment of the natural attenuation of chlorinated ethenes in an anaerobic contaminated aquifer in the Bitterfeld/Wolfen area using stable isotope techniques, microcosm studies and molecular biomarkers
Chemosphere 67 (2), 300 - 311
10.1016/j.chemosphere.2006.09.084
Nijenhuis, I., Renpenning, J., Kümmel, S., Richnow, H.H., Gehre, M. (2016):
Recent advances in multi-element compound-specific stable isotope analysis of organohalides: Achievements, challenges and prospects for assessing environmental sources and transformation
Trends Environ. Anal. Chem. 11 , 1 - 8
10.1016/j.teac.2016.04.001
Nijenhuis, I., Richnow, H.H. (2016):
Stable isotope fractionation concepts for characterizing biotransformation of organohalides
Curr. Opin. Biotechnol. 41 , 108 - 113
10.1016/j.copbio.2016.06.002
Nijenhuis, I., Schmidt, M., Pellegatti, E., Paramatti, E., Richnow, H.-H., Gargini, A. (2013):
A stable isotope approach for source apportionment of chlorinated ethene plumes at a complex multi-contamination events urban site
J. Contam. Hydrol. 153 , 92 - 105
10.1016/j.jconhyd.2013.06.004
Nijenhuis, I., Stelzer, N., Kästner, M., Richnow, H.-H. (2007):
Sensitive detection of anaerobic monochlorobenzene degradation using stable isotope tracers
Environ. Sci. Technol. 41 (11), 3836 - 3842
10.1021/es0621896
Nijenhuis, I., Stollberg, R., Lechner, U. (2018):
Anaerobic microbial dehalogenation and its key players in the contaminated Bitterfeld-Wolfen megasite
FEMS Microbiol. Ecol. 94 (4), fiy012
10.1093/femsec/fiy012
Nijenhuis, I., Uhlig, S., Kaschl, A., Nikolausz, M., Kästner, M. (2004):
Evidence for in situ natural attenuation of monochlorobenzene and chlorinated ethenes in an anaerobic contaminated aquifer
Abstr. Paper Am. Chem. Soc. 228 , U608 - U609
Nijenhuis, I., Zinder, S.H. (2005):
Characterization of hydrogenase and reductive dehalogenase activities of Dehalococcoides ethenogenes strain 195
Appl. Environ. Microb. 71 (3), 1664 - 1667
10.1128/AEM.71.3.1664-1667.2005
Nikolausz, M., Kappelmeyer, U., Nijenhuis, I., Ziller, K., Kästner, M. (2005):
Molecular characterization of dichloromethane-degrading Hyphomicrobium strains using 16S rDNA and DCM dehalogenase gene sequences
Syst. Appl. Microbiol. 28 (7), 582 - 587
10.1016/j.syapm.2005.03.011
Nikolausz, M., Nijenhuis, I., Ziller, K., Richnow, H.H., Kästner, M. (2006):
Stable carbon isotope fractionation during degradation of dichloromethane by methylotrophic bacteria
Environ. Microbiol. 8 (1), 156 - 164
10.1111/j.1462-2920.2005.00878.x
Peng, P., Lu, Y., Bosma, T.N.P., Nijenhuis, I., Nijsse, B., Shetty, S.A., Ruecker, A., Umanets, A., Ramiro-Garcia, J., Kappler, A., Sipkema, D., Smidt, H., Atashgahi, S. (2020):
Metagenomic- and cultivation-based exploration of anaerobic chloroform biotransformation in hypersaline sediments as natural source of chloromethanes
Microorganisms 8 (5), art. 665
10.3390/microorganisms8050665
Phillips, E., Bulka, O., Picott, K., Kümmel, S., Edwards, E., Nijenhuis, I., Gehre, M., Dworatzek, S., Webb, J., Sherwood Lollar, B. (2022):
Investigation of active site amino acid influence on carbon and chlorine isotope fractionation during reductive dechlorination
FEMS Microbiol. Ecol. 98 (8), fiac072
10.1093/femsec/fiac072
Phillips, E., De Vera, J., Kümmel, S., Bulka, O., Chen, W., Edwards, E., Nijenhuis, I., Gehre, M., Sherwood Lollar, B. (2026):
Isotopic fractionation and masking effects during biotransformation of chlorinated ethanes
Environ. Sci. Technol. 60 (22), 15940 - 15951
10.1021/acs.est.5c14089
Phillips, E., Picott, K., Kümmel, S., Bulka, O., Edwards, E., Wang, P.-H., Gehre, M., Nijenhuis, I., Lollar, B.S. (2024):
Vitamin B12 as a source of variability in isotope effects for chloroform biotransformation by Dehalobacter
MicrobiologyOpen 13 (4), e1433
10.1002/mbo3.1433
Pöritz, M., Goris, T., Wubet, T., Tarkka, M.T., Buscot, F., Nijenhuis, I., Lechner, U., Adrian, L. (2013):
Genome sequences of two dehalogenation specialists - Dehalococcoides mccartyi strains BTF08 and DCMB5 enriched from the highly polluted Bitterfeld region
FEMS Microbiol. Lett. 343 (2), 101 - 104
10.1111/1574-6968.12160
Pöritz, M., Schiffmann, C.L., Hause, G., Heinemann, U., Seifert, J., Jehmlich, N., von Bergen, M., Nijenhuis, I., Lechner, U. (2015):
Dehalococcoides mccartyi strain DCMB5 respires a broad spectrum of chlorinated aromatic compounds
Appl. Environ. Microb. 81 (2), 587 - 596
10.1128/AEM.02597-14
Puigserver, S., Herrero, J., Torres, M., Cortés, A., Nijenhuis, I., Kuntze, K., Parker, B.L., Carmona, J.M. (2016):
Reductive dechlorination in recalcitrant sources of chloroethenes in the transition zone between aquifers and aquitards
Environ. Sci. Pollut. Res. 23 (18), 18724 - 18741
10.1007/s11356-016-7068-4
Renpenning, J., Hitzfeld, K.L., Gilevska, T., Nijenhuis, I., Gehre, M., Richnow, H.-H. (2015):
Development and validation of an universal interface for compound-specific stable isotope analysis of chlorine (37Cl/35Cl) by GC-high-temperature conversion (HTC)-MS/IRMS
Anal. Chem. 87 (5), 2832 - 2839
10.1021/ac504232u
Renpenning, J., Keller, S., Cretnik, S., Shouakar-Stash, O., Elsner, M., Schubert, T., Nijenhuis, I. (2014):
Combined C and Cl isotope effects indicate differences between corrinoids and enzyme (Sulfurospirillum multivorans PceA) in reductive dehalogenation of tetrachloroethene, but not trichloroethene
Environ. Sci. Technol. 48 (20), 11837 - 11845
10.1021/es503306g
Renpenning, J., Nijenhuis, I. (2016):
Evaluation of the microbial reductive dehalogenation reaction using compound-specific stable isotope analysis (CSIA)
In: Adrian, L., Löffler, F.E. (eds.)
Organohalide-respiring bacteria
Springer, Berlin, Heidelberg, p. 429 - 453
10.1007/978-3-662-49875-0_18
Renpenning, J., Rapp, I., Nijenhuis, I. (2015):
Substrate hydrophobicity and cell composition influence the extent of rate limitation and masking of isotope fractionation during microbial reductive dehalogenation of chlorinated ethenes
Environ. Sci. Technol. 49 (7), 4293 - 4301
10.1021/es506108j
Schmidt, M., Lege, S., Nijenhuis, I. (2014):
Comparison of 1,2-dichloroethane, dichloroethene and vinyl chloride carbon stable isotope fractionation during dechlorination by two Dehalococcoides strains
Water Res. 52 , 146 - 154
10.1016/j.watres.2013.12.042
Schmidt, M., Wolfram, D., Birkigt, J., Ahlheim, J., Paschke, H., Richnow, H.-H., Nijenhuis, I. (2014):
Iron oxides stimulate microbial monochlorobenzene in situ transformation in constructed wetlands and laboratory systems
Sci. Total Environ. 472 , 185 - 193
10.1016/j.scitotenv.2013.10.116
Sohn, S.Y., Kuntze, K., Nijenhuis, I., Häggblom, M.M. (2018):
Evaluation of carbon isotope fractionation during anaerobic reductive dehalogenation of chlorinated and brominated benzenes
Chemosphere 193 , 785 - 792
10.1016/j.chemosphere.2017.11.089
Stelzer, N., Büning, C., Pfeifer, F., Dohrmann, A.B., Tebbe, C.C., Nijenhuis, I., Kästner, M., Richnow, H.H. (2006):
In situ microcosms to evaluate natural attenuation potentials in contaminated aquifers
Org. Geochem. 37 (10), 1394 - 1410
10.1016/j.orggeochem.2006.05.011
Stelzer, N., Imfeld, G., Thullner, M., Lehmann, J., Poser, A., Richnow, H.-H., Nijenhuis, I. (2009):
Integrative approach to delineate natural attenuation of chlorinated benzenes in anoxic aquifers
Environ. Pollut. 157 (6), 1800 - 1806
10.1016/j.envpol.2009.01.029
Vogel, M., Nijenhuis, I., Lloyd, J., Boothman, C., Pöritz, M., Mackenzie, K. (2018):
Combined chemical and microbiological degradation of tetrachloroethene during the application of Carbo-Iron at a contaminated field site
Sci. Total Environ. 628-629 , 1027 - 1036
10.1016/j.scitotenv.2018.01.310
Wang, Z., Yang, Y., Kümmel, S., Richnow, H.-H., Nijenhuis, I., Vogt, C. (2025):
Heterotrophic nitrate reduction potential of an aquifer microbial community from psychrophilic to thermophilic conditions
Sci. Total Environ. 967 , art. 178716
10.1016/j.scitotenv.2025.178716
Wienkenjohann, H., Bin Hudari, M.S., Mosthaf, K., Vogt, C., Nijenhuis, I., Rolle, M. (2025):
Combining microcosm biodegradation and reactive transport modeling to explore the feasibility of ATES-bioremediation approaches
Front. Water 7 , art. 1499448
10.3389/frwa.2025.1499448
Woods, A., Kuntze, K., Gelman, F., Halicz, L., Nijenhuis, I. (2018):
Variable dual carbon-bromine stable isotope fractionation during enzyme-catalyzed reductive dehalogenation of brominated ethenes
Chemosphere 190 , 211 - 217
10.1016/j.chemosphere.2017.09.128
Zhang, N., Bashir, S., Qin, J., Schindelka, J., Fischer, A., Nijenhuis, I., Herrmann, H., Wick, L.Y., Richnow, H.H. (2014):
Compound specific stable isotope analysis (CSIA) to characterize transformation mechanisms of α-hexachlorocyclohexane
J. Hazard. Mater. 280 , 750 - 757
10.1016/j.jhazmat.2014.08.046
Zhang, X., Zheng, Y., Su, Z., Wang, Z., Zhang, J., Jia, Z., Kümmel, S., Qin, C., Liu, Y., Wang, S., Nijenhuis, I., Richnow, H.H. (2024):
Anaerobic biotransformation of hexachlorocyclohexane isomers in aqueous condition: dual C-Cl isotope fractionation and impact on microbial community compositions
Water Res. 254 , art. 121389
10.1016/j.watres.2024.121389
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modified: 19.03.2024
Resp.: PD Dr. Ivonne Nijenhuis
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