Yoshiko Akamatsu, Ph.D. - Calico Skip to content 0% Calico Research & Technology Research & Technology Publications Drug Development Drug Development Patients Partnering Leadership Careers Job Openings PostDoc Program Mission and Values Leadership Research & Technology Drug Development Patients Partnering Collaborator Profiles People Publications News & Media Press Releases Calico Stories Life at Calico Careers Job Openings PostDoc Program Contact Us Back to Senior R&D Staff Yoshiko Akamatsu, Ph.D. Senior Director, Antibody Discovery and Engineering Yoshiko leads the discovery and optimization of therapeutic antibodies using cutting-edge technologies. About Yoshiko is responsible for designing therapeutic antibodies and advanced biologics modalities to identify promising leads for studies addressing unmet medical needs. Yoshiko joined Calico from AbbVie, where she led numerous biologics programs from exploratory concepts to candidate nomination, established a multi-specific biologics discovery platform team, and built an mRNA/LNP modality expert group as an internal gene delivery platform. Before AbbVie, Yoshiko worked at Abbott Biotherapeutics, Facet Biotech, PDL BioPharma and was an Associate Professor at the Institute for Genome Research, University of Tokushima, Japan. Education: Ph.D. and M.S. in Biophysics, Institute for Virus Research, Kyoto University, Kyoto, Japan B.S., School of Science, Kobe University, Kobe, Japan Featured Publications: CTLA4-Ig–based bifunctional costimulation Inhibitor blocks CD28 and ICOS signaling to prevent T cell priming and effector function Epitope and Fc-mediated cross-linking, but not high affinity, are critical for antitumor activity of CD137 agonist antibody with reduced liver toxicity See Other Senior R&D Staff Profiles Jeremy Willsey, Ph.D. Director, Translational Data Science Mariia Yuneva, Ph.D. Senior Principal Investigator Joe Arron, M.D., Ph.D. Head of Human Biology and Genetics Amos Baruch, Ph.D. Sr. Director, Head of Biomarker Development PREVIOUS BIO NEXT BIO About Us Research & Technology Drug Development Leadership Partnering Our Story Life at Calico Resources Publications Calico Stories News & Media Patients Contact Us Contact Us Join Us Follow Us X LinkedIn Privacy Policy Notice at Collection Terms of Use Code of Conduct 2026 Calico Life Sciences LLC. All rights reserved. Close