Joe Arron, M.D., Ph.D. - Calico Skip to content 0% Calico Research & Technology Research & Technology Publications Drug Development Drug Development Patients Partnering Leadership Careers Job Openings PostDoc Program Mission and Values Leadership Research & Technology Drug Development Patients Partnering Collaborator Profiles People Publications News & Media Press Releases Calico Stories Life at Calico Careers Job Openings PostDoc Program Contact Us Back to Senior R&D Staff Joe Arron, M.D., Ph.D. Head of Human Biology and Genetics Joe oversees the analysis of large-scale human datasets to discover, validate, and develop therapies for diseases of aging. About Joe coordinates the discovery, validation, and translation of therapeutic targets related to human diseases of aging, integrating computational analyses of large-scale datasets and experimental model systems. Before joining Calico, Joe served as Chief Scientific Officer and Head of Research and Development at Sonoma Biotherapeutics from 2023 to 2026, where he oversaw the development of engineered regulatory T cell therapies for autoimmune diseases. From 2021 to 2023, Joe directed discovery and translation of therapeutic targets related to human genetic variation as Chief Scientific Officer at 23andMe Therapeutics. At Genentech from 2006 to 2021, Joe led a laboratory that conducted translational research in respiratory diseases, contributing to multiple therapeutic targets and over 75 publications, and directed target discovery for the Immunology and Ophthalmology therapeutic areas as Vice President and Senior Fellow. Education: Postdoc in Pathology and Developmental Biology, Stanford University School of Medicine M.D., Weill Medical College of Cornell University Ph.D., The Rockefeller University A.B. in Chemistry, Princeton University Featured Publications: Targeted alveolar regeneration with Frizzled-specific agonists TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis See Other Senior R&D Staff Profiles Mariia Yuneva, Ph.D. Senior Principal Investigator Yoshiko Akamatsu, Ph.D. Senior Director, Antibody Discovery and Engineering Amos Baruch, Ph.D. Sr. Director, Head of Biomarker Development Bryson Bennett, Ph.D. Principal Investigator, Metabolomics & Lipidomics PREVIOUS BIO NEXT BIO About Us Research & Technology Drug Development Leadership Partnering Our Story Life at Calico Resources Publications Calico Stories News & Media Patients Contact Us Contact Us Join Us Follow Us X LinkedIn Privacy Policy Notice at Collection Terms of Use Code of Conduct 2026 Calico Life Sciences LLC. All rights reserved. Close