Bryson Bennett, Ph.D. - Calico
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Bryson Bennett, Ph.D.
Principal Investigator, Metabolomics & Lipidomics
Bryson uses mass spectrometry and stable isotope labeling to better understand metabolism in a variety of models of aging.
About
Bryson’s current research is focused on understanding endogenous metabolism in a variety of models of aging, from yeast to humans, using mass spectrometry and stable isotope labeling. This work includes systems-level analyses of metabolism for hypothesis generation work, biomarker identification, and as a tool to dissect the function of individual metabolic pathways.
Previously, he applied mass spectrometry and metabolomics tools to the problems of identifying and understanding metabolic targets for therapeutic intervention in oncology and viral infection. Prior to that, he studied metabolomics in the laboratory of Josh Rabinowitz at Princeton, where they developed stable isotope labeling techniques to determine absolute metabolite concentrations and metabolic fluxes in cells. The lab discovered fatty acid metabolism as a potential target for treating cytomegalovirus infection using these methods.
Education:
Ph.D. in Chemistry, Princeton University
B.S. in Chemistry, Stanford University
Featured Publications:
Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis
Automated preparation of plasma lipids, metabolites, and proteins for LC/MS-based analysis of a high-fat diet in mice
Calico Publications:
MAVEN2: An updated open-source mass spectrometry exploration platform
Novel insights from a multiomics dissection of the Hayflick limit
See Other Senior R&D Staff Profiles
Joe Arron, M.D., Ph.D.
Head of Human Biology and Genetics
Amos Baruch, Ph.D.
Sr. Director, Head of Biomarker Development
Tian-Quan Cai, Ph.D.
Head of Pharmacology/Drug Metabolism and Pharmacokinetics (DMPK)
Sandip Chatterjee, Ph.D.
Director, Software Engineering
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