Ari Firestone, Ph.D. - Calico
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Back to Senior R&D Staff
Ari Firestone, Ph.D.
Principal Investigator
Ari’s research focuses on identifying and validating novel therapeutic targets and strategies for the treatment of cancer.
About
A primary driver of the Firestone Lab’s work is the computational mining of large-scale functional genomics and phenotypic small-molecule screens to identify selective vulnerabilities in definable cancer subtypes.
Prior to joining Calico, Ari completed a postdoc in Kevin Shannon’s laboratory at the University of California at San Francisco working on novel strategies for targeting NRAS mutant hematological malignancies.
Education:
Postdoc, Laboratory of Kevin Shannon, University of California at San Francisco
Ph.D. in Chemical and Systems Biology, Stanford University
B.A. in Biology, Carleton College
Featured Publications:
Discovery of a potent chloroacetamide GPX4 inhibitor with bioavailability to enable target engagement in mice, a potential tool compound for inducing ferroptosis in vivo
Inhibition of aurora kinase induces endogenous retroelements to induce a type I/III IFN response via RIG-I.
Calico Publications:
Synthetic lethal interaction of SHOC2 depletion with MEK inhibition in RAS-driven cancers.
Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.
A three-drug combination to treat BRAF-mutant cancers
Awards:
Fellow of the Damon Runyon Cancer Research Foundation - 2012
See Other Senior R&D Staff Profiles
Madeleine Cule, Ph.D.
Director, Data Science
Brian Feng, Ph.D
Director, Cellular Phenotyping
Astrid Gillich, Ph.D.
Principal Investigator
Daniel Gottschling, Ph.D.
Distinguished Fellow
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