Aaron Nile, Ph.D. - Calico
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Back to Senior R&D Staff
Aaron Nile, Ph.D.
Principal Investigator
Aaron seeks to build novel discovery platforms, identify exploitable oncology targets and develop novel therapeutics. His research functions at the interface between biochemistry, structural biology and computing to enable drug discovery.
About
Aaron’s group is modality agnostic and exploits the “best” approach including bioactive peptides, degraders, small molecules, antibodies, covalent technologies and systems yet to be described.
Prior to joining Calico, Aaron completed a postdoc in Early Discovery Biochemistry at Genentech. There he developed and designed peptides through directed evolution, structural and in silico approaches that modulate Wnt-signaling. He also provided structural insights into how cell-surface FZD receptors recognize cis-unsaturated fatty acyl groups on Wnt ligands.
During his Ph.D. Aaron developed antagonistic small molecules that specifically disrupt PI4P signaling pathways in eukaryotic cells, superior to those directed against phosphatidylinositol hydroxyl kinases.
Education:
Postdoc in Early Discovery Biochemistry, Genentech
Ph.D. in Cell and Developmental Biology, University of North Carolina at Chapel Hill
B.S. in Molecular Genetics, The Ohio State University
Featured Publications:
A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells
PITPs as targets for selectively interfering with phosphoinositide signaling in cells
Calico Publications:
Structure of the p53 degradation complex from HPV16
Reversibly reactive affinity selection–mass spectrometry enables identification of covalent peptide binders.
Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6
See Other Senior R&D Staff Profiles
Fiona McAllister, Ph.D.
Director, Proteomics
Eugene Melamud, Ph.D.
Principal Investigator
Matt Onsum, Ph.D.
Head of AI/ML
Snahel Patel
Head of Small Molecule Drug Discovery
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