Johannes Riegler, Ph.D. - Calico
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Johannes Riegler, Ph.D.
Director, Preclinical Technologies
Johannes is developing non-invasive imaging techniques to study longitudinal changes in the physiology of aging animals and age-related pathologies.
About
Johannes’ Preclinical Imaging lab uses high-resolution MRI and advanced post-processing techniques to generate reliable in vivo biomarkers to better understand aging and to evaluate drug candidates which can prevent or reverse age-related changes.
Prior to Calico, as a postdoc with Joseph C. Wu at Stanford University, Johannes developed magnetic resonance imaging (MRI) based techniques to assess changes in cardiac function following cell transplantation and bioluminescence-based approaches to track cell survival. During a postdoc at Genentech with Richard A.D. Carano, he developed MRI-based techniques to elucidate the role of vascular inflammation in T-cell infiltration as well as ultrasound-based approaches to characterize the tumor microenvironment.
Education:
Postdoc with Joseph C. Wu at Stanford University, and with Richard A.D. Carano at Genentech
Ph.D. in Bioengineering, University College London
MRes. in Modelling Biological Complexity, University College London
M.Sc. and B.S. in Biotechnology, University of Natural Resources and Life Sciences, Vienna
Featured Publications:
Naked mole-rats maintain cardiac function and body composition well into their fourth decade of life
Human engineered heart muscles engraft and survive long term in a rodent myocardial infarction model
Calico Publications:
Intermittent fasting and caloric restriction interact with genetics to shape physiological health in mice
Automated cardiac MRI analysis for robust profiling of heart failure models in mice
Awards:
Erwin Schrödinger Fellowship, Austrian Science Foundation
See Other Senior R&D Staff Profiles
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Subhabrata Sanyal, Ph.D.
Head of Translational Neurosciences
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