Effects of a single oral administration of Epanolol on exercise tolerance in patients with stable effort angina pectoris - PubMed
This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!
Clipboard, Search History, and several other advanced features are temporarily unavailable.
Skip to main page content
An official website of the United States government
Here's how you know
The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you’re on a federal
government site.
The site is secure.
The https:// ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
Log in
Show account info
Close
Account
Logged in as:
username
Dashboard
Publications
Account settings
Log out
Access keys
NCBI Homepage
MyNCBI Homepage
Main Content
Main Navigation
Search:
Search
Advanced
Clipboard
User Guide
Save
Email
Send to
Clipboard
My Bibliography
Collections
Citation manager
Display options
Display options
Format
Abstract
PubMed
PMID
Save citation to file
Format:
Summary (text)
PubMed
PMID
Abstract (text)
CSV
Create file
Cancel
Email citation
Email address has not been verified. Go to
My NCBI account settings
to confirm your email and then refresh this page.
To:
Subject:
Body:
Format:
Summary
Summary (text)
Abstract
Abstract (text)
MeSH and other data
Send email
Cancel
Add to Collections
Create a new collection
Add to an existing collection
Name your collection:
Name must be less than 100 characters
Choose a collection:
Unable to load your collection due to an error
Please try again
Add
Cancel
Add to My Bibliography
My Bibliography
Unable to load your delegates due to an error
Please try again
Add
Cancel
Your saved search
Name of saved search:
Search terms:
Test search terms
Would you like email updates of new search results?
Saved Search Alert Radio Buttons
Yes
No
Email:
(change)
Frequency:
Monthly
Weekly
Daily
Which day?
The first Sunday
The first Monday
The first Tuesday
The first Wednesday
The first Thursday
The first Friday
The first Saturday
The first day
The first weekday
Which day?
Sunday
Monday
Tuesday
Wednesday
Thursday
Friday
Saturday
Report format:
Summary
Summary (text)
Abstract
Abstract (text)
PubMed
Send at most:
1 item
5 items
10 items
20 items
50 items
100 items
200 items
Send even when there aren't any new results
Optional text in email:
Save
Cancel
Create a file for external citation management software
Create file
Cancel
Your RSS Feed
Name of RSS Feed:
Number of items displayed:
5
10
15
20
50
100
Create RSS
Cancel
RSS Link
Copy
Actions
Cite
Collections
Add to Collections
Create a new collection
Add to an existing collection
Name your collection:
Name must be less than 100 characters
Choose a collection:
Unable to load your collection due to an error
Please try again
Add
Cancel
Permalink
Permalink
Copy
Display options
Display options
Format
AbstractPubMedPMID
Page navigation
Title & authors
Abstract
Publication types
MeSH terms
Substances
LinkOut - more resources
Title & authors
Abstract
Publication types
MeSH terms
Substances
LinkOut - more resources
Clinical Trial
Acta Cardiol
Actions
Search in PubMed
Search in NLM Catalog
Add to Search
. 1991;46(1):11-25.
Effects of a single oral administration of Epanolol on exercise tolerance in patients with stable effort angina pectoris
H Vandenbosch 
1
, J Piessens, H De Geest
Affiliations
Expand
Affiliation
1 Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
PMID:
1674394
Item in Clipboard
Clinical Trial
Effects of a single oral administration of Epanolol on exercise tolerance in patients with stable effort angina pectoris
H Vandenbosch et al.
Acta Cardiol.
1991.
Show details
Display options
Display options
Format
Abstract
PubMed
PMID
Acta Cardiol
Actions
Search in PubMed
Search in NLM Catalog
Add to Search
. 1991;46(1):11-25.
Authors
H Vandenbosch 
1
, J Piessens, H De Geest
Affiliation
1 Department of Cardiology, University Hospital Gasthuisberg, Leuven, Belgium.
PMID:
1674394
Item in Clipboard
Cite
Display options
Display options
Format
AbstractPubMedPMID
Abstract
A single oral dosage of 100, 200 or 300 mg Epanolol or placebo was administered in a randomized double-blind, cross-over fashion to 12 patients with stable effort angina. Symptom limited bicycle ergometer tests were performed before and 2 and 8 hours after each drug administration. Spontaneous diurnal and day to day differences in exercise tolerance and related analyzed variables were not present; 48 hours after drug intake a carry-over effect of the previous Epanolol administration could not be demonstrated. At each dose level of Epanolol, 2 hours after drug intake, heart rate and rate pressure product at peak exercise fell while exercise duration rose significantly. After 8 hours these effects were less marked. No significant differences between the 3 dose levels were found. In the pooled data of the 3 Epanolol doses, systolic blood pressure at peak exercise and maximal ischemic ST segment depression during exercise were also significantly reduced after 2 hours, while total performed external work rose. The percentage increase in heart rate during exercise after Epanolol administration was similar to the control tests at lower exercise levels but was less marked during the later stages of the test. Heart rate after Epanolol intake was percentage wise more reduced at higher exercise levels. Plasma levels of Epanolol were lower 8 hours after drug administration than after 2 hours. There was no correlation between plasma levels of Epanolol and the observed changes of any of the exercise variables 2 hours after drug intake.
PubMed Disclaimer
Publication types
Clinical Trial
Actions
Search in PubMed
Search in MeSH
Add to Search
Randomized Controlled Trial
Actions
Search in PubMed
Search in MeSH
Add to Search
MeSH terms
Administration, Oral
Actions
Search in PubMed
Search in MeSH
Add to Search
Adrenergic beta-Antagonists / administration & dosage*
Actions
Search in PubMed
Search in MeSH
Add to Search
Adrenergic beta-Antagonists / blood
Actions
Search in PubMed
Search in MeSH
Add to Search
Adrenergic beta-Antagonists / pharmacology
Actions
Search in PubMed
Search in MeSH
Add to Search
Angina Pectoris / drug therapy*
Actions
Search in PubMed
Search in MeSH
Add to Search
Benzeneacetamides*
Actions
Search in PubMed
Search in MeSH
Add to Search
Blood Pressure / drug effects
Actions
Search in PubMed
Search in MeSH
Add to Search
Circadian Rhythm
Actions
Search in PubMed
Search in MeSH
Add to Search
Electrocardiography / drug effects
Actions
Search in PubMed
Search in MeSH
Add to Search
Exercise Test / drug effects*
Actions
Search in PubMed
Search in MeSH
Add to Search
Heart Rate / drug effects
Actions
Search in PubMed
Search in MeSH
Add to Search
Humans
Actions
Search in PubMed
Search in MeSH
Add to Search
Male
Actions
Search in PubMed
Search in MeSH
Add to Search
Middle Aged
Actions
Search in PubMed
Search in MeSH
Add to Search
Propanolamines / administration & dosage*
Actions
Search in PubMed
Search in MeSH
Add to Search
Propanolamines / blood
Actions
Search in PubMed
Search in MeSH
Add to Search
Propanolamines / pharmacology
Actions
Search in PubMed
Search in MeSH
Add to Search
Time Factors
Actions
Search in PubMed
Search in MeSH
Add to Search
Substances
Adrenergic beta-Antagonists
Actions
Search in PubMed
Search in MeSH
Add to Search
Benzeneacetamides
Actions
Search in PubMed
Search in MeSH
Add to Search
Propanolamines
Actions
Search in PubMed
Search in MeSH
Add to Search
epanolol
Actions
Search in PubMed
Search in MeSH
Add to Search
LinkOut - more resources
Medical
MedlinePlus Health Information
[x]
Cite
Copy
Download .nbib
.nbib
Format:
AMA
APA
MLA
NLM
Send To
Clipboard
Email
Save
My Bibliography
Collections
Citation Manager
[x]
NCBI Literature Resources
MeSH
PMC
Bookshelf
Disclaimer
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
Follow NCBI
Twitter
Facebook
LinkedIn
GitHub
Connect with NLM
Twitter
SM-Facebook
SM-Youtube
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Web Policies
FOIA
HHS Vulnerability Disclosure
Help
Accessibility
Careers
NLM
NIH
HHS
USA.gov