Up to 11 years of experience with the Melody valved stent in the right ventricular outflow tract - PubMed
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. 2018 Oct 12;14(9):e988-e994.
doi: 10.4244/EIJ-D-18-00054.
Up to 11 years of experience with the Melody valved stent in the right ventricular outflow tract
Bjorn Cools 
1
, Steven Brown, Werner Budts, Ruth Heying, Els Troost, Derize Boshoff, Benedicte Eyskens, Marc Gewillig
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1 Division of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, Belgium.
PMID:
29957592
DOI:
10.4244/EIJ-D-18-00054
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Observational Study
Up to 11 years of experience with the Melody valved stent in the right ventricular outflow tract
Bjorn Cools et al.
EuroIntervention.
2018.
Free article
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. 2018 Oct 12;14(9):e988-e994.
doi: 10.4244/EIJ-D-18-00054.
Authors
Bjorn Cools 
1
, Steven Brown, Werner Budts, Ruth Heying, Els Troost, Derize Boshoff, Benedicte Eyskens, Marc Gewillig
Affiliation
1 Division of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, Belgium.
PMID:
29957592
DOI:
10.4244/EIJ-D-18-00054
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Aims:
The aim of the study was to report up to 11 years of follow-up after Melody valve implantation in the pulmonary position.
Methods and results:
This was a single-institution non-randomised prospective observational study of all Melody valves in the pulmonary position after discharge between 2006 and 2017 (n=188). Mean age was 19.4 years (SD 13.2). The indication was stenosis (45%), regurgitation (33%) and mixed (22%). Pre-stenting was performed in all except the initial four patients. In stenotic lesions the peak gradient was 36 mmHg PIG (SD 12.0) after 11 years and in regurgitant lesions the maximal regurgitation was 2/4. Stent fractures were observed in 8.6%; only one grade III fracture required redo PPVI. Surgical removal was carried out in seven (3.7%), redo PPVI in five (2.7%). Endocarditis was diagnosed in 19 (10.2%) patients at a median of 2.3 years (0.7-8.8) after Melody implantation. Three were surgically removed early because of persistent infection, 16 were sterilised; six required replacement (three surgical, three redo PPVI). There were no valve- or procedure-related deaths.
Conclusions:
The Melody valve shows a good preserved leaflet function up to 11 years after implantation. The main reason for graft failure was endocarditis, although in half of those patients no reintervention was needed. After pre-stenting, stent fractures led very exceptionally to reintervention.
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Cardiac Catheterization
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