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Page 1
1
Cite
BCH-2763, a novel potent parenteral thrombin inhibitor, is an effective antithrombotic agent in rodent models of arterial and venous thrombosis--comparisons with heparin, r-hirudin, hirulog, inogatran and argatroban.
Finkle CD, St Pierre A, Leblond L, Deschenes I, DiMaio J, Winocour PD.
Finkle CD, et al.
Thromb Haemost. 1998 Feb;79(2):431-8.
Thromb Haemost. 1998.
PMID: 9493603
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2
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Effective use of BCH-2763, a new potent injectable direct thrombin inhibitor, in combination with tissue plasminogen activator (tPA) in a rat arterial thrombolysis model.
Deschênes I, Finkle CD, Winocour PD.
Deschênes I, et al.
Thromb Haemost. 1998 Jul;80(1):186-91.
Thromb Haemost. 1998.
PMID: 9684808
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3
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Insertion of the Asp-Ser/Phe sequence in the P' position of hirutonin provides molecules having both antithrombin and disintegrin activity.
Leblond L, DiMaio J, Winocour PD.
Leblond L, et al. Among authors: winocour pd.
Thromb Res. 1999 Feb 15;93(4):171-81. doi: 10.1016/s0049-3848(98)00182-0.
Thromb Res. 1999.
PMID: 10064272
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4
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In vitro and in vivo properties of bicyclic lactam inhibitors: a novel class of low molecular weight peptidomimetic thrombin inhibitors.
Leblond L, Grouix B, Boudreau C, Yang Q, Siddiqui MA, Winocour PD.
Leblond L, et al. Among authors: winocour pd.
Thromb Res. 2000 Nov 1;100(3):195-209. doi: 10.1016/s0049-3848(00)00333-9.
Thromb Res. 2000.
PMID: 11108907
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5
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Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.
St-Denis Y, Augelli-Szafran CE, Bachand B, Berryman KA, DiMaio J, Doherty AM, Edmunds JJ, Leblond L, Lévesque S, Narasimhan LS, Penvose-Yi JR, Rubin JR, Tarazi M, Winocour PD, Siddiqui MA.
St-Denis Y, et al.
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3193-8. doi: 10.1016/s0960-894x(98)00550-2.
Bioorg Med Chem Lett. 1998.
PMID: 9873701
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6
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Antithrombotic effects of BCH 2763, a new direct thrombin inhibitor, in a canine model of venous thrombosis.
McClanahan TB, Ignasiak DP, Juneau P, Finkle C, Winocour PD, Gallagher KP.
McClanahan TB, et al. Among authors: winocour pd.
J Thromb Thrombolysis. 1999 Jun;7(3):301-6. doi: 10.1023/a:1008987211850.
J Thromb Thrombolysis. 1999.
PMID: 10375391
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Item in Clipboard
7
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Potent and selective bicyclic lactam inhibitors of thrombin. Part 4: transition state inhibitors.
Bachand B, Tarazi M, St-Denis Y, Edmunds JJ, Winocour PD, Leblond L, Siddiqui MA.
Bachand B, et al. Among authors: winocour pd.
Bioorg Med Chem Lett. 2001 Feb 12;11(3):287-90. doi: 10.1016/s0960-894x(00)00636-3.
Bioorg Med Chem Lett. 2001.
PMID: 11212093
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8
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Novel bicyclic lactam inhibitors of thrombin: highly potent and selective inhibitors.
St-Denis Y, Lévesque S, Bachand B, Edmunds JJ, Leblond L, Préville P, Tarazi M, Winocour PD, Siddiqui MA.
St-Denis Y, et al. Among authors: winocour pd.
Bioorg Med Chem Lett. 2002 Apr 22;12(8):1181-4. doi: 10.1016/s0960-894x(02)00131-2.
Bioorg Med Chem Lett. 2002.
PMID: 11934583
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9
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Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues.
Lévesque S, St-Denis Y, Bachand B, Préville P, Leblond L, Winocour PD, Edmunds JJ, Rubin JR, Siddiqui MA.
Lévesque S, et al. Among authors: winocour pd.
Bioorg Med Chem Lett. 2001 Dec 17;11(24):3161-4. doi: 10.1016/s0960-894x(01)00661-8.
Bioorg Med Chem Lett. 2001.
PMID: 11720865
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10
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Incorporation of an Asp-Ser sequence to form an RGDS-like motif in hirutonin: the effect on in vitro platelet function.
van Wyk V, Leblond L, Winocour PD, Devine DV, Gyongyossy-Issa MI.
van Wyk V, et al. Among authors: winocour pd.
Thromb Res. 2000 Aug 15;99(4):343-52. doi: 10.1016/s0049-3848(00)00257-7.
Thromb Res. 2000.
PMID: 10963785
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